IMPACT OF THE GENE EXPRESSION LEVEL AND INTERMOLECULAR INTERACTION NETWORKS ON RADIORESISTANCE OF TUMOR CELLS

Despite its efficacy, radiation therapy faces the challenges connected with accelerated reproduction of tumor cells and radioresistance malignant neoplasms.
 The aim study was to analyze impact gene expression level intermolecular interaction networks on development cell radioresistance.
 Materials Methods. authors used 4 lines: (K562, HCT-116p53 (+/+), (–/–), Me45. To line transcriptome. Affymetrix high-density hybridization DNA chips (HGU133A series) were used. Bioinformatic analysis dynamics performed using original Gene Selector program. Intermolecular studied STRING online system.
 Results. After exposure ionizing at a dose Gy, DAAM1, IFNAR2, PALLD, STK17A genes increases in K562 decreases (–/–) Numerous protein complexes found system. Thus, influence activity some particles network interactions. Selected PALLD protein-protein encoded by TNK2, PTBP2 DVL2; STAT2, IRF9, JAK1, GNB2L1 IFNAR1; LPP ACTN2 can be as potential targets. Their modulation increase response neoplasm radiation.